Mesenchymal stromal cells and their secretome: new therapeutic perspectives for skeletal muscle regeneration

M Sandonà, L Di Pietro, F Esposito… - … in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are multipotent cells found in different tissues: bone
marrow, peripheral blood, adipose tissues, skeletal muscle, perinatal tissues, and dental …

Different donors mesenchymal stromal cells secretomes reveal heterogeneous profile of relevance for therapeutic use

A Assoni, G Coatti, MC Valadares… - Stem cells and …, 2017 - liebertpub.com
Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder caused by null mutations
in the dystrophin gene. Although the primary defect is the deficiency of muscle dystrophin …

The current landscape of the mesenchymal stromal cell secretome: a new paradigm for cell-free regeneration

VBR Konala, MK Mamidi, R Bhonde, AK Das… - Cytotherapy, 2016 - Elsevier
The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their
multipotentiality have rendered them attractive to researchers and clinicians. In addition to …

The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

P Kumar, S Kandoi, R Misra, S Vijayalakshmi… - Cytokine & growth factor …, 2019 - Elsevier
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …

Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning

JR Ferreira, GQ Teixeira, SG Santos… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells
that have been isolated from a variety of tissues, and possess multipotent differentiation …

The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

Mesenchymal stromal cells; a new horizon in regenerative medicine

S Tavakoli, HR Ghaderi Jafarbeigloo… - Journal of cellular …, 2020 - Wiley Online Library
In recent decades, mesenchymal stromal cells (MSCs) biomedical utilizing has attracted
worldwide growing attention. After the first report of the human MSCs obtaining from the …

[HTML][HTML] Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine

A González-González, D García-Sánchez… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due
to their easy isolation from various adult tissues, their ability of homing to injury sites and …

Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements

J Doorn, G Moll, K Le Blanc… - … Engineering Part B …, 2012 - liebertpub.com
Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …