Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Glutamate is an excitatory neurotransmitter in the mammalian central nervous system and a
neurotoxin (excitotoxin) that has the potential to destroy neurones by activation of ionotropic …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Beneficial effects of glutamate-receptor antagonists in models of neurological disorders are
often used to support the notion that endogenous excitotoxicity (ie resulting from …

Glutamate kills neurons by excitotoxicity, which is caused by sustained activation of
glutamate receptors. In recent years, it has been shown that glutamate can also be toxic to …

Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and
plays an important role in many central nervous system (CNS) diseases, including CNS …

Much work has been carried out in recent years showing that elevated glutamate levels in
the extracellular environment of the central nervous system play a pivotal role in …

Glutamate signalling plays key physiological roles in excitatory neurotransmission and CNS
plasticity, but also mediates excitotoxicity, the process responsible for triggering …