Pseudomonas aeruginosa, a major cause of nosocomial and chronic infections, is
considered a paradigm of antimicrobial resistance development. However, the evolutionary …

We compared the dynamics and mechanisms of resistance development to ceftazidime,
meropenem, ciprofloxacin, and ceftolozane-tazobactam in wild-type (PAO1) and mutator …

One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for
developing antimicrobial resistance to nearly all available antipseudomonal agents through …

Combination therapy with several antibiotics is one strategy that has been applied in order
to limit the spread of antimicrobial resistance. We compared the de novo evolution of …

Pseudomonas aeruginosa is an opportunistic pathogen that causes considerable morbidity
and mortality, specifically during intensive care. Antibiotic-resistant variants of this organism …

The emergence of antimicrobial drug resistance is of enormous public concern due to the
increased risk of delayed treatment of infections, the increased length of hospital stays, the …

Because adaptation depends upon the fixation of novel beneficial mutations, the fitness
effects of beneficial mutations that are substituted by selection are key to our understanding …

Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute
and chronic infections. An increasing number of isolates have mutations that make them …

Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has
joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It …