The mechanisms responsible for producing abnormal spermatozoa in the ejaculate are
relatively unknown. Numerous studies have now shown the presence of nuclear DNA strand …

With the successful use of Assisted Reproduction, in particular intracytoplasmic sperm
injection (ICSI), to treat infertile couples we have become less discriminating with the quality …

Numerous studies have shown the presence of DNA strand breaks in human ejaculated
spermatozoa. The nature of this nuclear anomaly and its relationship to patient etiology is …

[Frontiers in Bioscience 11, 1491-1499, May 1, 2006] 1491 Origin and biological
significance of DNA fragmentation in human sperm Page 1 [Frontiers in Bioscience 11, 1491-1499 …

This paper reviews the possible origin of sperm DNA fragmentation and focuses on the
nuclear events associated with spermiogenesis as a potential source of genetic instability …

The molecular basis of many forms of male infertility is poorly defined. One area of research
that has been studied intensely is the integrity of the DNA in the nucleus of mature …

Spermatozoa have the task to deliver an intact paternal genome to the oocyte and to support
a successful embryo development. The high levels of sperm DNA fragmentation (sDF) found …

The integrity of the paternal genome is of paramount importance in the initiation and
maintenance of a pregnancy in vivo and in vitro. The presence in the embryonic genome of …

In the first part of this report we investigate whether chromatin anomalies in human
spermatozoa can influence fertilization after intracytoplasmic sperm injection (ICSI). We …

Sperm DNA fragmentation (sDF) represents a threat to male fertility, human reproduction
and the health of the offspring. The causes of sDF are still unclear, even if apoptosis …