Abstract The Ashwell–Morell receptor (AMR) of hepatocytes, originally termed the hepatic
asialoglycoprotein receptor, was the first cellular receptor to be identified and isolated and …

Lactoferrin binds to rat hepatic lectin 1 (RHL1), the major subunit of the asialoglycoprotein
(ASGP) receptor, with high affinity, by a galactose-independent mechanism. To better …

The endocytic Ashwell-Morell receptor (AMR) of hepatocytes detects pathogen remodeling
of host glycoproteins by neuraminidase in the bloodstream and mitigates the lethal …

The mammalian asialoglycoprotein receptor (ASGPR) is located on the sinusoidal
membrane of hepatocytes where it binds and endocytoses galactose-terminated …

The Ashwell receptor, the major lectin of hepatocytes, rapidly clears from blood circulation
glycoproteins bearing glycan ligands that include galactose and N-acetylgalactosamine …

Mammalian hepatic asialoglycoprotein receptors (ASGP-R) are composed of two unique,
but closely related polypeptides, which in the rat are designated rat hepatic lectins 1 and 2/3 …

Previous studies have shown that loss of terminal sialic acid causes enhanced von
Willebrand factor (VWF) clearance through the Ashwell-Morrell receptor (AMR). In this study …

The hepatic receptor for asialoglycoproteins was initially demonstrated in the early 1970s by
the seminal studies of Ashwell, Morel], and their colleagues during investigations of the …

The Gal/GalNAc-specific lectin on rat peritoneal macrophages (macrophage
asialoglycoprotein binding protein, M-ASGP-BP) is structurally similar to rat hepatic …

The asialoglycoprotein receptor (ASGPR) is the first lectin discovered in mammals. Despite
its significant biological role in binding and internalization of desialyated glycoproteins, at …