Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

The covalent modification of proteins with ubiquitin is required for accurate cell division in all
eukaryotes. Ubiquitylation depends on an enzymatic cascade, in which E3 enzymes recruit …

The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …

A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …

The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to
cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute …

The ubiquitin pathway plays a central role in the regulation of cell growth and cell
proliferation by controlling the abundance of key cell cycle proteins. Increasing evidence …

Proliferation is driven by an intricate machinery, the smooth operation of which is essential
for the development and survival of the organism. The central task of this machinery is to …

The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication
and separation, ensuring that genomic information is faithfully and perpetually maintained …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …

Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many
cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is …