[HTML][HTML] Multi-omics characterizes the effects and mechanisms of CD1d in nonalcoholic fatty liver disease development
Q Zheng, C Xue, X Gu, D Shan, Q Chu… - Frontiers in Cell and …, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is a class of metabolic-associated liver diseases.
Aberrant lipid consumption plays an important role in NAFLD pathogenesis. It has been …
Aberrant lipid consumption plays an important role in NAFLD pathogenesis. It has been …
[HTML][HTML] Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis
W Wang, Y Kong, X Wang, Z Wang, C Tang, J Li… - Cell Communication and …, 2023 - Springer
Due to the complexity and incomplete understanding of the crosstalk between liver and
adipose tissue, especially the processes of hepatic lipogenesis and adipogenic …
adipose tissue, especially the processes of hepatic lipogenesis and adipogenic …
[HTML][HTML] Activation of CDK4 triggers development of non-alcoholic fatty liver disease
The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process.
Here, we show that activation of cdk4 triggers the development of NAFLD. We found that …
Here, we show that activation of cdk4 triggers the development of NAFLD. We found that …
[HTML][HTML] Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis
J Xu, S Chen, W Wang, SM Lam, Y Xu, S Zhang, H Pan… - Science Bulletin, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies, ranging
from steatosis to nonalcoholic steatohepatitis (NASH). The factors promoting the progression …
from steatosis to nonalcoholic steatohepatitis (NASH). The factors promoting the progression …
[HTML][HTML] LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by
excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and …
excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and …
[HTML][HTML] CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
H Zeng, H Qin, M Liao, E Zheng, X Luo, A Xiao, Y Li… - Molecular …, 2022 - Elsevier
Objective Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to
nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in …
nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in …
Combined with multiplex and network analysis to reveal the key genes and mechanisms of nonalcoholic fatty liver disease
Z Yang, X Han, K Wang, J Fang, Z Wang… - International …, 2023 - Elsevier
Abstract Background and Aims Non-alcoholic fatty liver disease (NAFLD) has become a
significant cause of chronic liver disease in developed countries, as a result of the worldwide …
significant cause of chronic liver disease in developed countries, as a result of the worldwide …
[HTML][HTML] DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression
Q Li, W Wang, F Duan, Y Wang, S Chen, K Shi… - Cellular and Molecular …, 2024 - Elsevier
Background & Aims Nonalcoholic fatty liver disease is the most prevalent chronic liver
disease and threats to human health. Gut dysbiosis caused by lipopolysaccharide (LPS) …
disease and threats to human health. Gut dysbiosis caused by lipopolysaccharide (LPS) …
MD2 deficiency prevents high‐fat diet‐induced AMPK suppression and lipid accumulation through regulating TBK1 in non‐alcoholic fatty liver disease
W Luo, L Ye, X Hu, M Wang, M Wang… - Clinical and …, 2022 - Wiley Online Library
Background Non‐alcoholic fatty liver disease (NAFLD) is the most predominant form of liver
diseases worldwide. Recent evidence shows that myeloid differentiation factor 2 (MD2), a …
diseases worldwide. Recent evidence shows that myeloid differentiation factor 2 (MD2), a …
[HTML][HTML] HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse
H Tsuru, M Osaka, Y Hiraoka, M Yoshida - Scientific Reports, 2020 - nature.com
Excessive intake of fat causes accumulation of fat in liver, leading to non-alcoholic fatty liver
disease (NAFLD). High-fat diet (HFD) upregulates the expression of Factor D, a complement …
disease (NAFLD). High-fat diet (HFD) upregulates the expression of Factor D, a complement …