Contribution of uric acid to cancer risk, recurrence, and mortality

MA Fini, A Elias, RJ Johnson, RM Wright - Clinical and translational …, 2012 - Springer
Two risk factors for the development and progression of cancers that are amenable to life
style modification are chronic inflammation and the metabolic syndrome. This review …

[HTML][HTML] Friend or foe? An unrecognized role of uric acid in cancer development and the potential anticancer effects of uric acid-lowering drugs

S Mi, L Gong, Z Sui - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists.
Mets has an intimate relationship with the incidence and development of various cancers. As …

The good, the bad and the new about uric acid in cancer

S Allegrini, M Garcia-Gil, R Pesi, M Camici, MG Tozzi - Cancers, 2022 - mdpi.com
Simple Summary The concentration of uric acid in blood is sex-, age-and diet-dependent
and is maintained close to its maximal solubility, indicating that it plays some important role …

Hyperuricemia and gout are associated with cancer incidence and mortality: a meta‐analysis based on cohort studies

Y Xie, P Xu, K Liu, S Lin, M Wang, T Tian… - Journal of cellular …, 2019 - Wiley Online Library
The association between hyperuricemia or gout and cancer risk has been investigated in
various published studies, but their results are conflicting. We conducted a meta‐analysis to …

Serum uric acid increases risk of cancer incidence and mortality: a systematic review and meta‐analysis

S Yan, P Zhang, W Xu, Y Liu, B Wang… - Mediators of …, 2015 - Wiley Online Library
SUA is a potent antioxidant and thus may play a protective role against cancer. Many
epidemiological studies have investigated this hypothesis but provided inconsistent and …

[HTML][HTML] Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

A Yiu, M Van Hemelrijck, H Garmo, L Holmberg… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Objectives Serum uric acid has been suggested to be associated with cancer risk. We aimed
to study the association between serum uric acid and cancer incidence in a large Swedish …

Xanthine oxidoreductase in cancer: more than a differentiation marker

MG Battelli, L Polito, M Bortolotti… - Cancer medicine, 2016 - Wiley Online Library
Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism
and is present in two interconvertible forms, which may utilize O2 or NAD+ as electron …

U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia

WT Crawley, CG Jungels, KR Stenmark, MA Fini - Redox Biology, 2022 - Elsevier
Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

Serum uric acid and risk of cancer mortality in a large prospective male cohort

AM Strasak, K Rapp, W Hilbe, W Oberaigner… - Cancer causes & …, 2007 - Springer
Objective To examine the prognostic role of serum uric acid (SUA) for cancer mortality in
apparently healthy men across a wide age range. Methods Prospective data from a large …

Serum uric acid levels and cancer mortality risk among males in a large general population-based cohort study

N Taghizadeh, JM Vonk, HM Boezen - Cancer Causes & Control, 2014 - Springer
Purpose Serum uric acid (SUA) has antioxidant capacities and therefore may protect against
the development of cancer. Few epidemiological studies have tested this hypothesis, and …