Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

A variety of in vivo models have increased understanding of the role of Wnt signaling in
bone since mutations in the LRP5 gene were found in human bone disorders. Canonical …

Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density
diminishing, and degeneration of bone microstructure, which is accompanied by a tendency …

The Wnt signaling pathway plays an important role not only in embryonic development but
also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt …

Studies concerning the pathophysiological connection between obesity and osteoporosis
are currently an intriguing area of research. Although the onset of these two diseases can …

Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …

Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling
(canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the …

Wnt signaling plays a central role in many processes during embryonic development and in
later stages of life. At least three distinct wnt signaling pathways have been described. In …

Osteoporosis and osteoporosis-related fractures are growing problems with the aging
population and are associated with significant morbidity and mortality. At this time, other than …

Wnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …