The third variable region, V3, of the gp120 surface envelope glycoprotein is an
approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded …

The V1/V2 region and the V3 loop of the human immunodeficiency virus type I (HIV-1)
envelope (Env) protein are targets for neutralizing antibodies and also play an important …

Antibodies (Abs) specific for the V3 loop of the HIV-1 gp120 envelope neutralize most tier 1
and many tier 2 viruses and are present in essentially all HIV-infected individuals as well as …

The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly
neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the …

We recently derived a CD4-independent virus from HIV-1/IIIB, termed IIIBx, which interacts
directly with the chemokine receptor CXCR4 to infect cells. To address the underlying …

The binding of human immunodeficiency virus type 1 (HIV-1) to the cellular receptor CD4
has been suggested to induce conformational changes in the viral envelope glycoproteins …

The HIV-1 envelope trimer adopts a quaternary conformation that effectively shields
neutralization-sensitive domains and thus represents a major obstacle for natural and …

Binding of the third variable region (V3) of the HIV-1 envelope glycoprotein gp120 to the cell-
surface coreceptors CCR5 or CXCR4 during viral entry suggests that there are conserved …

Ascertaining the function of the third hypervariable (V3) region of the HIV-1 surface
glycoprotein, gp120, may be essential for understanding several important features of HIV-1 …

The production of immunoglobulin capable of neutralizing the infectivity of a virus represents
one of the most remarkable molecular accomplishments of the host's available immune …