Data Analysis of DNA MethylationEpigenome-Wide Association Studies (EWAS): A Guide to the Principles of Best Practice
Array-based EWAS have become an increasingly popular technique to identify population
epigenetic effects, particularly in humans. With the arrival of nonhuman species arrays, such …
epigenetic effects, particularly in humans. With the arrival of nonhuman species arrays, such …
DNA Methylation: Methods and Analyses
TJ Gorrie-Stone - 2019 - repository.essex.ac.uk
Epigenome-wide Association Studies (EWAS) have been a popular method to investigate
the genome over the past decade. From these experiments, more than 75,000 samples have …
the genome over the past decade. From these experiments, more than 75,000 samples have …
[HTML][HTML] Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
[HTML][HTML] DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 …
C Gallego-Fabrega, C Carrera, E Muiño, J Montaner… - Clinical …, 2015 - Springer
Background DNA methylation is a heritable and stable epigenetic mark implicated in
complex human traits. Epigenome-wide association studies (EWAS) using array-based …
complex human traits. Epigenome-wide association studies (EWAS) using array-based …
Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time
M Forest, KJ O'Donnell, G Voisin, H Gaudreau… - Epigenetics, 2018 - Taylor & Francis
Epigenome-wide association studies (EWAS) have focused primarily on DNA methylation as
a chemically stable and functional epigenetic modification. However, the stability and …
a chemically stable and functional epigenetic modification. However, the stability and …
[HTML][HTML] A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association …
B Lehne, AW Drong, M Loh, W Zhang, WR Scott… - Genome biology, 2015 - Springer
DNA methylation plays a fundamental role in the regulation of the genome, but the optimal
strategy for analysis of genome-wide DNA methylation data remains to be determined. We …
strategy for analysis of genome-wide DNA methylation data remains to be determined. We …
MethLAB: a graphical user interface package for the analysis of array-based DNA methylation data
Recent evidence suggests that DNA methylation changes may underlie numerous complex
traits and diseases. The advent of commercial, array-based methods to interrogate DNA …
traits and diseases. The advent of commercial, array-based methods to interrogate DNA …
Epigenome-wide association study (EWAS): Methods and applications
M Tanić - Epigenetics methods, 2020 - Elsevier
Since their inception less than a decade ago, epigenome-wide association studies (EWAS)
have become widely adopted to help decipher disease etiology and to identify disease …
have become widely adopted to help decipher disease etiology and to identify disease …
[HTML][HTML] Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array
Background Measurement of genome-wide DNA methylation (DNAm) has become an
important avenue for investigating potential physiologically-relevant epigenetic changes …
important avenue for investigating potential physiologically-relevant epigenetic changes …
Evaluating reliability of DNA methylation measurement
R Cao, W Guan - Epigenome-Wide Association Studies: Methods and …, 2022 - Springer
DNA methylation is a widely studied epigenetic phenomenon. Alterations in methylation
patterns influence human phenotypes and risk of disease. The Illumina Infinium …
patterns influence human phenotypes and risk of disease. The Illumina Infinium …