Mutagenesis of the human A3 adenosine receptor (AR) suggested that certain amino acid
residues contributed differently to ligand binding and activation processes. Here we …

Potent and selective A1-adenosine receptor (AR) antagonists (derivatives of xanthine or
other heterocyclic structures) have been developed during the past ten years. Recently, the …

Antagonism of the human A2A receptor has been implicated as a point of therapeutic
intervention in the alleviation of the symptoms associated with Parkinson's disease. This is …

Adenosine is a purine nucleoside, responsible for the regulation of a wide range of
physiological and pathophysiological conditions by binding with four G-protein-coupled …

Abstract A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to
be overexpressed in a large number of cancer types. This receptor plays an important role in …

The production of adenosine represents a critical endogenous mechanism for regulating
immune and inflammatory responses during conditions of stress, injury, or infection …

Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …

Adenosine is an endogenous nucleoside that modulates many physiological processes. Its
actions are mediated by interaction with specific cell membrane receptors. Four subtypes of …

Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Adenosine is a ubiquitous autacoid that acts on four defined receptors, named A (1), A (2A),
A (2B) and A (3). Although the biological activity of adenosine has been known for more than …