Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

E Ellwardt, F Zipp - Experimental neurology, 2014 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central
nervous system (CNS) and one of the leading causes of neurological deficits and disability …

Neurodegeneration in autoimmune CNS inflammation

J Herz, F Zipp, V Siffrin - Experimental neurology, 2010 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system, in which the myelin sheath has been considered to be the primary target for …

What drives disease in multiple sclerosis: inflammation or neurodegeneration?

H Lassmann - Clinical and Experimental Neuroimmunology, 2010 - Wiley Online Library
Multiple sclerosis (MS) is defined as a chronic inflammatory disease of the central nervous
system, which leads to focal inflammatory demyelinated lesions with secondary …

[HTML][HTML] The molecular basis of neurodegeneration in multiple sclerosis

H Lassmann, J van Horssen - FEBS letters, 2011 - Elsevier
Studies aimed to elucidate the pathogenesis of the disease and to find new therapeutic
options for multiple sclerosis (MS) patients heavily rely on experimental autoimmune …

Neuroinflammation, neurodegeneration and regeneration in multiple sclerosis: intercorrelated manifestations of the immune response

T Koudriavtseva, C Mainero - Neural regeneration research, 2016 - journals.lww.com
Multiple sclerosis (MS) is a chronic immune-mediated inflammatory-demyelinating disorder
of the central nervous system, with a strong neurodegenerative component. The question …

The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use

D Birmpili, I Charmarke Askar, K Bigaut… - International journal of …, 2022 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …

Neurodegeneration in multiple sclerosis: novel treatment strategies

F Luessi, V Siffrin, F Zipp - Expert Review of Neurotherapeutics, 2012 - Taylor & Francis
In recent years it has become clear that the neuronal compartment already plays an
important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course …

Macrophages and neurodegeneration

JJA Hendriks, CE Teunissen, HE de Vries… - Brain Research …, 2005 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Demyelination is a classical feature of MS lesions, and neurological …

Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases

L Tian, L Ma, T Kaarela, Z Li - Journal of neuroinflammation, 2012 - Springer
The central nervous system (CNS) is now known to actively communicate with the immune
system to control immune responses both centrally and peripherally. Within the CNS, while …

Molecular pathogenesis of neuroinflammation

M Bradl, R Hohlfeld - Journal of Neurology, Neurosurgery & Psychiatry, 2003 - jnnp.bmj.com
The past few years have seen significant progress towards understanding the mechanisms
of immune surveillance and inflammation in the nervous system. In this review, the …