[HTML][HTML] Association of alpha-crystallin with fiber cell plasma membrane of the eye lens accompanied by light scattering and cataract formation
α-crystallin is a major protein found in the mammalian eye lens that works as a molecular
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …
Alpha-Crystallin Association with the Model of Human and Animal Eye Lens-Lipid Membranes Is Modulated by Surface Hydrophobicity of Membranes
R Timsina, G Trossi-Torres, J Thieme, M O'Dell… - Current eye …, 2022 - Taylor & Francis
Purpose This research aims to probe the interaction of α-crystallin with a model of human,
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …
[HTML][HTML] Understanding the α-crystallin cell membrane conjunction
SP Su, JD McArthur, MG Friedrich, RJW Truscott… - Molecular …, 2011 - ncbi.nlm.nih.gov
Purpose It is well established that levels of soluble α-crystallin in the lens cytoplasm fall
steadily with age, accompanied by a corresponding increase in the amount of membrane …
steadily with age, accompanied by a corresponding increase in the amount of membrane …
α-Crystallin chaperone-like activity and membrane binding in age-related cataracts
BA Cobb, JM Petrash - Biochemistry, 2002 - ACS Publications
α-Crystallin, the major protein component of the vertebrate lens, is thought to play a critical
role in the maintenance of transparency through its ability to inhibit stress-induced protein …
role in the maintenance of transparency through its ability to inhibit stress-induced protein …
Lens α-crystallin: function and structure
J Horwitz, MP Bova, LL Ding, DA Haley, PL Stewart - Eye, 1999 - nature.com
Abstract α-Crystallin is a major lens protein, comprising up to 40% of total lens proteins,
where its structural function is to assist in maintaining the proper refractive index in the lens …
where its structural function is to assist in maintaining the proper refractive index in the lens …
The lens epithelium: Focus on the expression and function of the α-crystallin chaperones
UP Andley - The international journal of biochemistry & cell biology, 2008 - Elsevier
Lens epithelial cells are the parental cells responsible for growth and development of the
transparent ocular lens. Many elegant investigations into their biology have focused on the …
transparent ocular lens. Many elegant investigations into their biology have focused on the …
Modulation of α‐crystallin chaperone activity: A target to prevent or delay cataract?
Cataract, loss of eye lens transparency, is the leading cause of blindness worldwide. α‐
Crystallin, initially known as one of the major structural proteins of the eye lens, is composed …
Crystallin, initially known as one of the major structural proteins of the eye lens, is composed …
Effects of α-crystallin on lens cell function and cataract pathology
UP Andley - Current molecular medicine, 2009 - ingentaconnect.com
The development of cataracts is a debilitating eye condition which is common in elderly
patients and afflicts millions worldwide. Cataracts result from the deposition of aggregated …
patients and afflicts millions worldwide. Cataracts result from the deposition of aggregated …
[HTML][HTML] Characterization of α-crystallin-plasma membrane binding
BA Cobb, JM Petrash - Journal of Biological Chemistry, 2000 - ASBMB
α-Crystallin, a large lenticular protein complex made up of two related subunits (αA-and αB-
crystallin), is known to associate increasingly with fiber cell plasma membranes with age …
crystallin), is known to associate increasingly with fiber cell plasma membranes with age …
Membrane insertion of αA-crystallin is oligomer-size dependent
Vertebrate lens is one of the tissues with the highest soluble protein concentration. The
predominant soluble proteins in lens fiber cells are crystallins, and among them, α-crystallins …
predominant soluble proteins in lens fiber cells are crystallins, and among them, α-crystallins …