Bioanalysis (quantification of drug/metabolite residue in biological fluids and tissues) plays
an important role in support of drug efficacy and safety studies during drug development …

There are many ocular diseases still presenting unmet medical needs. Therefore, new
ophthalmologic drugs are being developed. Bioanalysis of eye compartments (along with …

Ocular pharmacokinetic (PK) and safety studies in animals are essential components in the
drug development pipeline. Ocular PK studies are designed to assess absorption …

This book's subject is ocular pharmacokinetics, pharmacodynamics, and toxicology. There
are detailed chapters on study design, analysis, and routes to regulatory approval for …

The eye is a complex organ composed of multiple tissues in anterior and posterior eye
segments. Malfunctions of any of these tissues can lead to ocular diseases and loss of …

This study describes the development and validation of a new liquid chromatography–
tandem mass spectrometry (MS/MS) method capable of simultaneous quantitation of seven …

This chapter deals with the methodology associated with the determination of ocular
pharmacokinetics, an associated topic that will be combined with the primary topic will be …

Abstract Development of ocular products and novel delivery systems for the treatment of
retinal and other ocular conditions is an active area of drug development. In the United …

Ophthalmic diseases include both those analogous to systemic diseases (eg, inflammation,
infection, neuronal degeneration) and not analogous (eg, cataract, myopia). Many anterior …

The study of pharmacokinetic processes—absorption, distribution, and elimination—is
fundamental to determining the appropriate dosing regimen for an individual patient …