Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery

T Jiang, Z Zhang, Y Zhang, H Lv, J Zhou, C Li, L Hou… - Biomaterials, 2012 - Elsevier
Dual-functional liposomes with pH-responsive cell-penetrating peptide (CPP) and active
targeting hyaluronic acid (HA) were fabricated for tumor-targeted drug delivery. A series of …

A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system

Q Zhang, J Tang, L Fu, R Ran, Y Liu, M Yuan, Q He - Biomaterials, 2013 - Elsevier
Tumor-oriented nanocarrier drug delivery approaches with pH-sensitivity have been
drawing considerable attentions over the years. Here we described a liposomal delivery …

Coadministration of oligomeric hyaluronic acid-modified liposomes with tumor-penetrating peptide-iRGD enhances the antitumor efficacy of doxorubicin against …

C Deng, Q Zhang, Y Fu, X Sun, T Gong… - ACS applied materials …, 2017 - ACS Publications
A safe and efficient tumor-targeting strategy based on oligomeric hyaluronic acid (HA)
modification and coadministration of tumor-penetrating peptide-iRGD was successfully …

Hyaluronic acid-based pH-sensitive polymer-modified liposomes for cell-specific intracellular drug delivery systems

M Miyazaki, E Yuba, H Hayashi, A Harada… - Bioconjugate …, 2018 - ACS Publications
For the enhancement of therapeutic effects and reduction of side effects derived from
anticancer drugs in cancer chemotherapy, it is imperative to develop drug delivery systems …

Hyaluronic acid modified pH-sensitive liposomes for targeted intracellular delivery of doxorubicin

SR Paliwal, R Paliwal, GP Agrawal… - Journal of liposome …, 2016 - Taylor & Francis
Context: Surface-modified pH-sensitive liposomal system may be useful for intracellular
delivery of chemotherapeutics. Objective: Achieving site-specific targeting with over …

Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity

Y Zhao, W Ren, T Zhong, S Zhang, D Huang… - Journal of controlled …, 2016 - Elsevier
The pH environment in gliomas is acidic. Therefore, in the present research, we selected our
previously reported tumor-specific pH-responsive peptide H 7 K (R 2) 2 as a targeting …

Intracellular delivery and antitumor effects of pH-sensitive liposomes based on zwitterionic oligopeptide lipids

R Mo, Q Sun, N Li, C Zhang - Biomaterials, 2013 - Elsevier
pH-sensitive liposomes (HHG2C18-L and PEGHG2C18-L) based on zwitterionic
oligopeptide lipids as anticancer drug carriers were developed and evaluated for effective …

A pH-responsive cell-penetrating peptide-modified liposomes with active recognizing of integrin αvβ3 for the treatment of melanoma

K Shi, J Li, Z Cao, P Yang, Y Qiu, B Yang… - Journal of Controlled …, 2015 - Elsevier
The use of pH-responsive cell-penetrating peptides (CPPs) is an attractive strategy for drug
delivery in vivo, however, they still could not actively target to the desired sites. Here, we …

pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy

YT Chiang, CL Lo - Biomaterials, 2014 - Elsevier
This study presents a tumor-extracellular matrix pH-induced targeting liposome (ECM-
targeting liposomes), crosslinked from methoxy-poly (ethylene glycol)-b-poly (N-2 …

An efficient PEGylated liposomal nanocarrier containing cell-penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery

Y Ding, D Sun, GL Wang, HG Yang, HF Xu… - International Journal …, 2015 - Taylor & Francis
Cell-penetrating peptides (CPPs) as small molecular transporters with abilities of cell
penetrating, internalization, and endosomal escape have potential prospect in drug delivery …