Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy

X Han, S Hu, Q Yang, X Sang, D Tang, G Cao - Phytomedicine, 2022 - Elsevier
Background Asthma characterized by airway remodeling is a multiple pulmonary disease,
which is associated with various physiological processes including inflammation reaction …

Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying paeoniflorin for the treatment of allergic asthma

Q Shou, L Jin, J Lang, Q Shan, Z Ni, C Cheng… - Frontiers in …, 2019 - frontiersin.org
Objectives: Asthma is a chronic airway inflammatory disease, which is characterized by
airway remodeling, hyperreactivity and shortness of breath. Paeoniflorin is one of the major …

Immunoregulatory effects of paeoniflorin exerts anti-asthmatic effects via modulation of the Th1/Th2 equilibrium

T Zhang, Z Yang, S Yang, J Du, S Wang - Inflammation, 2015 - Springer
Paeoniflorin has been demonstrated to exert anti-inflammatory and immunomodulatory
effects in the animal study. In this study, we investigated immunoregulatory effects of …

Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7‑TGF‑β pathway in allergic rhinitis

Y Jin, A Zhang - Molecular Medicine Reports, 2022 - spandidos-publications.com
Total glucosides of paeony (TGP), an active ingredient extracted from the root of Paeonia
alba, has been reported to display an anti‑inflammatory effect. However, the effect of TGP on …

Paeoniflorin attenuates allergic inflammation in asthmatic mice

J Sun, J Wu, C Xu, Q Luo, B Li, J Dong - International …, 2015 - Elsevier
Paeoniflorin (PF), one of the major active ingredients of Chinese peony, has demonstrated
anti-inflammatory and immunoregulatory effects. However, it has remained unclear whether …

Paeoniflorin protects against lipopolysaccharide-induced acute lung injury in mice by alleviating inflammatory cell infiltration and microvascular permeability

H Zhou, D Bian, X Jiao, Z Wei, H Zhang, Y Xia… - Inflammation …, 2011 - Springer
Objective The present study aims to explore the effects of paeoniflorin (PF), a monoterpene
glycoside isolated from the roots of Paeonia lactiflora Pallas, on acute lung injury (ALI) and …

Effect of paeoniflorin on acute lung injury induced by influenza A virus in mice. Evidences of its mechanism of action

W Yu, M Zeng, P Xu, J Liu, H Wang - Phytomedicine, 2021 - Elsevier
Background Influenza often leads to acute lung injury (ALI). Few therapeutics options such
as vaccines and other antiviral drugs are available. Paeoniflorin is a monoterpene glucoside …

Paeonol Ameliorates Ovalbumin‐Induced Asthma through the Inhibition of TLR4/NF‐κB and MAPK Signaling

Y Tang, W Huang, Q Song, X Zheng… - Evidence‐based …, 2018 - Wiley Online Library
Asthma is a chronic inflammatory disease of the airways, with complex signaling pathways
involved in its pathogenesis. It was reported that paeonol attenuated airway inflammation of …

Total glucosides of peony improve ovalbumin-induced allergic asthma by inhibiting mast cell degranulation

Q Shou, J Lang, L Jin, M Fang, B Cao, Y Cai… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Paeonia lactiflora Pall.(peony) is a medicinal plant used in
the Xiaoqinglong decoction, a commonly prescribed traditional Chinese medicine for …

Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex

S Wang, T Wuniqiemu, W Tang, F Teng, Q Bian… - International …, 2021 - Elsevier
Allergic asthma is a common chronic inflammatory disease characterized by airway
inflammation, mucus hypersecretion and airway remodeling. Autophagy is a highly …