There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Abstract Purpose of Review Osteoarthritis (OA) is the most common form of arthritis and a
major source of pain and disability worldwide. OA-associated pain is usually refractory to …

Pain is a major clinical problem of osteoarthritis (OA). Recently, OA has been thought to be a
disease of the whole joint with both destruction of cartilage and inflammatory components …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

There are over 100 different types of arthritis and each can differ greatly in their aetiology
and pathophysiology; however, one characteristic that is common to all arthritic conditions is …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

Pain in the peripheral joints is an increasingly common problem, resulting in significant
patient disability and health-care expenditure. Osteoarthritis (OA), a syndrome of joint pain …

OA is a chronic arthritic disease characterized by pain, local tissue damage and attempts at
tissue repair. Historically, cartilage damage was believed to be the hallmark of OA. However …

Pain is the defining symptom of osteoarthritis (OA), yet available treatment options, of which
NSAIDs are the most common, provide inadequate pain relief and are associated with …