Background: Computed tomographic (CT) measures of lung density are potential
intermediate study endpoints for clinical studies but to do so, the clinical associations of …

Background: Emphysema is an important component of COPD; however, in previous studies
of the correlation between airflow limitation (AFL) and computed tomography (CT) lung …

Background Emphysema and small airway disease both contribute to chronic obstructive
pulmonary disease (COPD), a disease characterised by accelerated decline in lung …

RATIONALE Recent evidence indicates that the rate of lung function decline is steepest in
mild COPD and slower in moderate to severe COPD. The current study assessed whether …

Background Low body weight is associated with poor prognosis in patients with chronic
obstructive pulmonary disease (COPD). However, it is not known whether gender modifies …

Background Recent evidence indicates that the rate of lung function decline is steepest in
mild COPD and slower in moderate to severe COPD. The current study assessed whether …

Methods We analyzed data from a large multicenter cohort (COPDGene) which included
current and former smokers (age 45-80 years). Smoking burden was ascertained by …

Rationale: Lung volumes identify the “susceptible smokers” who progress to develop
spirometric COPD, which seems to be a heterogenous process with staggered onset of …

Rationale: Forced expiratory volume in 1 second (FEV1) is a complex heritable trait, with
both environmental risk factors such as cigarette smoking, and genetic risk factors such as …

We thank FAA Mohamed Hoesein and P. Zanen for their interest in our work [ 1]. In our
study, we performed secondary analyses on data from the Lung Health Study (LHS)[ 2]. We …