Background Although biological resources are essential for basic and preclinical research in
the oncological field, those of sarcoma are not sufficient for rapid development of the …

Tumor microenvironment has been implicated in tumor development and progression. As a
three‐dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture …

Recent advances in biofabrication technologies, such as cell culture systems, and
biomaterials have led to the development of three-dimensional (3D) cell culture platforms …

Organoids are a class of multicellular structures with the capability of self-organizing and the
characteristic of original tissues, they are generated from stem cells in 3D culture in vitro …

Tumor models have created new avenues for personalized medicine and drug
development. A new culture model derived from a three-dimensional system, the tumor …

In vitro analysis of intestinal epithelium has been hindered by a lack of suitable culture
systems useful for gastrointestinal research. To overcome the problem, an air liquid interface …

Establishing a valid in vitro model to represent tumor heterogeneity and biology is critical but
challenging. Tumor organoids are self‐assembled three‐dimensional cell clusters which are …

During the past decade, the three-dimensional organoid technology has sprung up and
become more and more popular among researchers. Organoids are the miniatures of in vivo …

Sarcoma is a complex and heterogeneous cancer that has been difficult to study in vitro.
While two-dimensional (2D) cell cultures and mouse models have been the dominant …

Introduction Sarcoma clinical outcomes have been stagnant for decades due to
heterogeneity of primaries, lack of comprehensive preclinical models, and rarity of disease …