Highly diastereoselective four-component synthesis of polysubstituted 2-piperidinones with three and four stereogenic centers
AN Vereshchagin, KA Karpenko, MN Elinson… - Research on Chemical …, 2020 - Springer
A novel four-component diastereoselective synthesis of polysubstituted 2-piperidinones is
reported. The Michael addition–Mannich cascade of benzylidenemalononitriles or …
reported. The Michael addition–Mannich cascade of benzylidenemalononitriles or …
One-pot five-component high diastereoselective synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitriles, dialkyl malonates and ammonium …
AN Vereshchagin, KA Karpenko, MN Elinson… - Molecular Diversity, 2020 - Springer
A novel five-component diastereoselective synthesis of polysubstituted 2-piperidinones is
reported. The Knoevenagel condensation–Michael addition–Mannich cascade of two …
reported. The Knoevenagel condensation–Michael addition–Mannich cascade of two …
Four-component stereoselective synthesis of tetracyano-substituted piperidines
AN Vereshchagin, KA Karpenko, MN Elinson… - Research on Chemical …, 2018 - Springer
A novel four-component stereoselective synthesis of polysubstituted piperidines is reported.
The Knoevenagel–Michael–Mannich cascade of two equivalents of aromatic aldehydes …
The Knoevenagel–Michael–Mannich cascade of two equivalents of aromatic aldehydes …
Synthesis of polysubstituted 2-piperidinones via a Michael addition/nitro-Mannich/lactamization cascade
H Liu, Z Zhou, Q Sun, Y Li, Y Li, J Liu… - ACS Combinatorial …, 2012 - ACS Publications
An efficient and practical method has been developed for the diversity-oriented synthesis of
polysubstituted 2-piperidinones via four-component reaction between substituted …
polysubstituted 2-piperidinones via four-component reaction between substituted …
One-pot synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitromethane, ammonium acetate, and dialkyl malonates
H Liu, Q Sun, Z Zhou, J Liu, J Yang, C Wang - Monatshefte für Chemie …, 2013 - Springer
A pseudo-five-component reaction for one-pot synthesis of polysubstituted 2-piperidinones
from two equivalent aromatic aldehydes, nitromethane, ammonium acetate, and dialkyl …
from two equivalent aromatic aldehydes, nitromethane, ammonium acetate, and dialkyl …
Diastereoselective Synthesis of and Mechanistic Understanding for the Formation of 2‐Piperidinones from Imines and Cyano‐Substituted Anhydrides
MJ Di Maso, KM Snyder… - … A European Journal, 2016 - Wiley Online Library
Piperidinones are synthesized in a single step from imines and 2‐cyano glutaric anhydrides.
The reaction provides the products in good diastereoselectivity and generates a quaternary …
The reaction provides the products in good diastereoselectivity and generates a quaternary …
Highly diastereoselective multicomponent synthesis of pyridinium-substituted piperidin-2-ones with three stereogenic centres
AD Vinokurov, TM Iliyasov, KA Karpenko… - Mendeleev …, 2023 - Elsevier
Abstract The Michael–Mannich–cyclization cascade of dicyano olefins, 1-(2-alkoxy-2-
oxoethyl) pyridin-1-ium halogenides, aromatic aldehydes and ammonium acetate provides …
oxoethyl) pyridin-1-ium halogenides, aromatic aldehydes and ammonium acetate provides …
Highly diastereoselective synthesis of pyridinium-substituted piperidin-2-ones from pyridinium ylides, aldehydes, Michael acceptors, and ammonium acetate
AD Vinokurov, TM Iliyasov, KA Karpenko… - Chemistry of …, 2023 - Springer
A novel four-component diastereoselective synthesis of piperidin-2-one salts containing a
quaternized pyridine unit is reported. The Michael–Mannich cascade was conducted using …
quaternized pyridine unit is reported. The Michael–Mannich cascade was conducted using …
Synthesis and stereochemistry of highly crowded N-benzylpiperidones
SD Dindulkar, P Parthiban, VG Puranik… - Journal of Molecular …, 2012 - Elsevier
A series of N-benzylated 3, 5-diakyl-2, 6-diarylpiperidin-4-ones 4–8 were conveniently
synthesized in significant yields of 68–88% by N-benzylation of the corresponding 2, 6-diaryl …
synthesized in significant yields of 68–88% by N-benzylation of the corresponding 2, 6-diaryl …
Highly diastereoselective multicomponent synthesis of 2-piperidone-substituted pyridinium salts with three and four stereogenic centers
AD Vinokurov, TM Iliyasov, KA Karpenko, YV Derkach… - Tetrahedron, 2023 - Elsevier
abstract A novel four-component (five-molecular) diastereoselective synthesis of pyridinium
salts of 2-piperidinones is reported. The Knoevenagel–Michael–Mannich cascade of …
salts of 2-piperidinones is reported. The Knoevenagel–Michael–Mannich cascade of …