The exposome and health: Where chemistry meets biology

R Vermeulen, EL Schymanski, AL Barabási, GW Miller - Science, 2020 - science.org
Despite extensive evidence showing that exposure to specific chemicals can lead to
disease, current research approaches and regulatory policies fail to address the chemical …

The importance of the biological impact of exposure to the concept of the exposome

KK Dennis, SS Auerbach, DM Balshaw… - Environmental …, 2016 - ehp.niehs.nih.gov
Background: The term “exposome” was originally coined in 2005 and defined as the totality
of exposures throughout the lifetime. The exposome provides an excellent scientific …

The nature of nurture: refining the definition of the exposome

GW Miller, DP Jones - Toxicological sciences, 2014 - academic.oup.com
Historical debates concerning human biology and behavior have frequently focused on
contributions of nature, ie, the inherited characteristics with which we are born, and nurture …

The exposome: molecules to populations

MM Niedzwiecki, DI Walker… - Annual review of …, 2019 - annualreviews.org
Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …

The exposome and toxicology: a win–win collaboration

R Barouki, K Audouze, C Becker, L Blaha… - Toxicological …, 2022 - academic.oup.com
The development of the exposome concept has been one of the hallmarks of environmental
and health research for the last decade. The exposome encompasses the life course …

Implications of the exposome for exposure science

SM Rappaport - Journal of exposure science & environmental …, 2011 - nature.com
During the 1920s, the forerunners of exposure science collaborated with health
professionals to investigate the causes of occupational diseases. With the birth of US …

Exposure science and the exposome: an opportunity for coherence in the environmental health sciences

PJ Lioy, SM Rappaport - Environmental health perspectives, 2011 - ehp.niehs.nih.gov
The field of exposure science began with qualitative observations and quantitative
measurements of air contaminants to aid our under standing of exposure–disease …

The Eco‐Exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals

S Scholz, JW Nichols, BI Escher… - Environmental …, 2022 - Wiley Online Library
Organisms are exposed to ever‐changing complex mixtures of chemicals over the course of
their lifetime. The need to more comprehensively describe this exposure and relate it to …

[HTML][HTML] What is new in the exposome?

P Vineis, O Robinson, M Chadeau-Hyam… - Environment …, 2020 - Elsevier
The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …

[HTML][HTML] Merging the exposome into an integrated framework for “omics” sciences

EJ Price, CM Vitale, GW Miller, A David, R Barouki… - IScience, 2022 - cell.com
The exposome concept encourages holistic consideration of the non-genetic factors
(environmental exposures including lifestyle) that influence an individual's health over their …