Black seed thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin‐induced diabetic male wistar rats

HMA Abdelrazek, OE Kilany… - Oxidative medicine …, 2018 - Wiley Online Library
Diabetes mellitus is one of the metabolic diseases having several complications. Nigella
sativa oil (NSO) might have beneficial effects in the treatment of diabetic complications …

Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β‐cells of streptozotocin‐induced diabetic rats

NE Abdelmeguid, R Fakhoury, SM Kamal… - Journal of …, 2010 - Wiley Online Library
Background: The present study investigated the effects of Nigella sativa aqueous extract and
oil, as well as thymoquinone, on serum insulin and glucose concentrations in streptozotocin …

Thymoquinone, the most prominent constituent of Nigella sativa, attenuates liver damage in streptozotocin-induced diabetic rats via regulation of oxidative stress …

SA Almatroodi, AM Alnuqaydan, MA Alsahli, AA Khan… - Applied Sciences, 2021 - mdpi.com
Diabetes mellitus (DM) is a multifaceted metabolic disorder that results in dysfunction and
failure of various organs. The present study aimed to evaluate the role of Thymoquinone …

Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin‐Induced Diabetic Rats Fed with a High‐Fat Diet

M Balbaa, M El-Zeftawy, D Ghareeb… - Oxidative Medicine …, 2016 - Wiley Online Library
The black cumin (Nigella sativa)“NS” or the black seeds have many pharmacological
activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic …

Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats

L Pari, C Sankaranarayanan - Life sciences, 2009 - Elsevier
AIMS: The present study was designed to evaluate the antihyperglycemic potential of
thymoquinone (TQ), major constituent of Nigella sativa seeds on the activities of key …

Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats

C Sankaranarayanan, L Pari - Chemico-biological interactions, 2011 - Elsevier
The present study was aimed to investigate the effect of thymoquinone (TQ) on pancreatic
insulin levels, tissue antioxidant and lipid peroxidation (LPO) status in streptozotocin (STZ) …

Pharmacotherapy with thymoquinone improved pancreatic β-cell integrity and functional activity, enhanced islets revascularization, and alleviated metabolic and …

AG El-Shemi, OA Kensara, A Alsaegh, MH Mukhtar - Pharmacology, 2017 - karger.com
Aims: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on
streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying …

RETRACTED ARTICLE: Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced …

S Alimohammadi, R Hobbenaghi, J Javanbakht… - Diagnostic …, 2013 - Springer
Background Diabetes in humans induces chronic complications such as cardiovascular
damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common …

Antidiabetic potential of Nigella sativa L seed oil in alloxaninduced diabetic rabbits

MT Akhtar, R Qadir, I Bukhari, RA Ashraf, Z Malik… - Tropical Journal of …, 2020 - ajol.info
Purpose: To evaluate the antidiabetic, hypolipidemic and antioxidant potential of seed oil of
Nigella sativa L (NSO). Methods: Nigella sativa seed oil (NSO) was extracted with Soxhlet …

Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats

RJ Al Wafai - Pancreas, 2013 - journals.lww.com
Objective The aim of this study was to investigate the effect of Nigella sativa and
thymoquinone (TQ) on oxidative stress, cyclooxygenase-2 (COX-2), and intracellular …