Radiotherapy of Human Xenograft NSCLC Tumors in Nude Mice with a 90Y-Labeled Anti-Tissue Factor Antibody

B Wang, M Berger, G Masters, E Albone… - Cancer biotherapy & …, 2005 - liebertpub.com
Tissue factor (TF) is a type I transmembrane protein and the initiator of the extrinsic blood
coagulation pathway. TF plays a critical role in tumor development and its overexpression is …

Tumour-expressed tissue factor inhibits cellular cytotoxicity

C Li, LM Colman, MEW Collier, CE Dyer… - Cancer Immunology …, 2006 - Springer
Aims: The association between tissue factor (TF) expression and increased rate of tumour
metastasis is well established. In this study, we have examined the hypothesis that the …

Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis

M Sawada, S Miyake, S Ohdama, O Matsubara… - British journal of …, 1999 - nature.com
Tissue factor (TF) is an initiator of the extrinsic cascade of blood coagulation. Although
recent studies have revealed a relationship between metastatic properties and TF …

Characterization of human tissue factor (TF)–specific monoclonal antibodies prepared using a rapid immunization protocol

C Chen, Q Yang, S Patel, Y Lei, L McAleer, J Singleton… - Hybridoma, 2005 - liebertpub.com
Tissue factor (TF) plays an important, physiological role in hemostasis. Recent studies have
demonstrated the over-expression of TF in a number of solid tumor types and its …

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer

JG Wang, JE Geddings, MM Aleman… - Blood, The Journal …, 2012 - ashpublications.org
Cancer patients often have an activated clotting system and are at increased risk for venous
thrombosis. In the present study, we analyzed tissue factor (TF) expression in 4 different …

Tissue factor pathway inhibitor reduces experimental lung metastasis of B16 melanoma

A Amirkhosravi, T Meyer, JY Chang… - Thrombosis and …, 2002 - thieme-connect.com
The importance of tissue factor (TF) in tumor biology has been highlighted by studies
suggesting its involvement in cell signaling, metastasis and angiogenesis. Since many …

Contribution of host-derived tissue factor to tumor neovascularization

J Yu, L May, C Milsom, GM Anderson… - … , and vascular biology, 2008 - Am Heart Assoc
Objective—The role of host-derived tissue factor (TF) in tumor growth, angiogenesis, and
metastasis has hitherto been unclear and was investigated in this study. Methods and …

Tissue factor: A conventional or alternative target in cancer therapy

A Eisenreich, J Bolbrinker, U Leppert - Clinical Chemistry, 2016 - academic.oup.com
BACKGROUND Tissue factor (TF) is an evolutionary conserved glycoprotein that plays an
important role in the pathogenesis of cancer. TF is expressed in 2 naturally occurring protein …

Combination antibody therapy targeting both xenograft-and host-derived tissue factor leads to potent tumor inhibition

CV Ngo, CA Manning, F McCabe, H Millar, MT Nakada… - Cancer Research, 2005 - AACR
Abstract 548 It has long been recognized that cancer patients suffer from an increased
incidence of thromboembolic complications. One of the major culprits leading to this state of …

Systematic study of tissue factor expression in solid tumors

JS de Bono, JR Harris, SM Burm… - Cancer …, 2023 - Wiley Online Library
Background Elevated tissue factor (TF) expression, although restricted in normal tissue, has
been reported in multiple solid cancers, and expression has been associated with poor …