Vaccines have been a hugely successful public health intervention, virtually eliminating
many once common diseases of childhood. However, they have had less success in …

T lymphocytes play a central role in the generation of a protective immune response in many
microbial infections. After immunization, dendritic cells take up microbial antigens and traffic …

Background Resident memory T cells have emerged as key players in the immune response
generated against a number of pathogens. Their ability to take residence in non-lymphoid …

Respiratory viral infections present a major threat to global health and prosperity. Over the
past century, several have developed into crippling pandemics, including the SARS-CoV-2 …

Immunological memory is critical for immune protection, particularly at epithelial sites, which
are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ …

Historically, the gold-standard benchmark for vaccine immunogenicity has been the
induction of neutralizing antibodies detectable in the serum of peripheral blood. However, in …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

The adaptive immune system has evolved a unique capacity to remember a pathogen
through the generation of memory T cells, which rapidly protect the host in the event of …

Highlights•Tissue-resident memory T (T RM) cell development after respiratory virus
infection.•Lung T RM cell characteristics, regulation, and function.•T RM cells confer optimal …