Mammalian chromosomes are organized into megabase-sized compartments that are
further subdivided into topologically associating domains (TADs). While the formation of …

The genome folds into a hierarchy of three-dimensional structures within the nucleus. At the
sub-megabase scale, chromosomes form topologically associating domains (TADs) …

Abstract Background Topologically associating domains (TADs) are important building
blocks of three-dimensional genome architectures. The formation of TADs has been shown …

The human genome can be segmented into topologically associating domains (TADs),
which have been proposed to spatially sequester genes and regulatory elements through …

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

The three-dimensional organization of chromosomes is tightly related to their biological
function. Both imaging and chromosome conformation capture studies have revealed …

Chromosome conformation capture approaches have shown that interphase chromatin is
partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological …

Chromatin looping plays a pivotal role in gene expression and other biological processes
through bringing distal regulatory elements into spatial proximity. The formation of chromatin …

Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

Mammalian genomes are organized into compartments, topologically-associating domains
(TADs) and loops to facilitate gene regulation and other chromosomal functions …