[HTML][HTML] The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat
R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
Abstract Lipoprotein (a)[Lp (a)] concentrations are regulated by the LPA gene mainly via the
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
[HTML][HTML] A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region [S]
Lipoprotein (a)[Lp (a)] concentrations are among the strongest genetic risk factors for
cardiovascular disease and present pronounced interethnic and interindividual differences …
cardiovascular disease and present pronounced interethnic and interindividual differences …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels
W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
[HTML][HTML] Comprehensive Analysis of the Genetic Variation in the LPA Gene from Short-Read Sequencing
RO Betschart, G Koliopanos, P Garg, L Guo, M Rossi… - BioMed, 2024 - mdpi.com
Lipoprotein (a)(Lp (a)) is a risk factor for cardiovascular diseases and mainly regulated by
the complex LPA gene. We investigated the types of variation in the LPA gene and their …
the complex LPA gene. We investigated the types of variation in the LPA gene and their …
[HTML][HTML] Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein (a) in 10,910 individuals
S Di Maio, R Grüneis, G Streiter, C Lamina… - Genome medicine, 2020 - Springer
Background The concentrations of the highly atherogenic lipoprotein (a)[Lp (a)] are mainly
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …
Ancestry specific distribution of LPA Kringle IV-Type-2 genetic variants highlight associations to apo (a) copy number, glucose and hypertension.
Background: High Lp (a) levels contribute to atherosclerotic cardiovascular disease and are
tightly regulated by the LPA gene. Lp (a) levels have an inverse correlation with LPA Kringle …
tightly regulated by the LPA gene. Lp (a) levels have an inverse correlation with LPA Kringle …
[HTML][HTML] The effect of LPA Thr3888Pro on lipoprotein (a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G> A
R Grüneis, C Lamina, S Di Maio, S Schönherr… - Atherosclerosis, 2022 - Elsevier
Background and aims High lipoprotein (a)[Lp (a)] concentrations are associated with
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …
Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease
JF Schachtl-Riess, A Kheirkhah, R Grüneis… - Journal of the American …, 2021 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) concentrations are a major independent risk
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …