DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

DNA topoisomerases (topos) are essential enzymes that regulate the topological state of
DNA during cellular processes such as replication, transcription, recombination, and …

Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the
development of anticancer agents. In this study, a series of 1, 3-benzoazolyl-substituted …

Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents
with demonstrated clinical effects on human malignancies. However, the clinical uses of …

Human DNA topoisomerases represent one of the key targets of modern chemotherapy. An
emerging group of catalytic inhibitors of human DNA topoisomerase IIα comprises a new …

DNA topoisomerases comprise an important family of enzymes that catalyse the induction of
topological changes (eg relaxation/supercoiling, catenation/decatenation and …

Drugs that inhibit or poison the function of topoisomerase (topo) enzymes are one of the
mainstays of cancer chemotherapy, and include some of the most widely used anticancer …

Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause
cancer cell death by inducing DNA damage, which mechanism of action is also associated …

Background: The family of DNA topoisomerases comprises a group of enzymes that catalyse
the induction of topological changes to DNA. These enzymes play a role in the cell …

Topoisomerases (Topo I and Topo II) are very important players in DNA replication, repair,
and transcription, and are a promising class of antitumor target. In present study, a series of …