Cardiotoxicity is one of the serious side effects of antineoplastic treatments that leads to high
morbidity and mortality around the world (1). Anticancer drugs such as doxorubicin (Dox) …

This study investigated the effects of berberine, a natural alkaloid, on doxorubicin-induced
cardiotoxicity in mice. Mice were injected intraperitoneally with saline 10 ml/kg (n= 10) …

Cardiotoxic side-effects of doxorubicin limit the clinical use of this anti-cancer agent. Iron
chelators have been studied as protectors against doxorubicin-induced cardiotoxicity. These …

Doxorubicin as a chemotherapeutic drug is widely used for the treatment of patients with
cancer. However, clinical use of this drug is hampered by its cardiotoxicity, which is …

The clinical use of doxorubicin, an effective anticancer drug, is severely hampered by its
cardiotoxicity. Berberine, a botanical alkaloid, has been reported to possess cardioprotective …

Background Doxorubicin is a chemotherapeutic agent that is widely used in the treatment of
malignancies. However, its clinical application is limited, mainly because of its cardiotoxic …

Aim of Study: The present work aimed to examine the efficacy of two ayurvedic formulations,
Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) …

Doxorubicin (DOX) is a potent and broad‑spectrum anthracycline chemotherapeutic agent,
but dose‑dependent cardiotoxic side effects limit its clinical application. This toxicity is …

Doxorubicin is a widely used and promising anticancer drug; however, a severe dose-
dependent cardiotoxicity hampers its therapeutic value. Doxorubicin may cause acute and …

Doxorubicin (DOX) is used in the treatment of cancer. However, cardiotoxicity is its major
dose-limiting factor. Mechanism of DOX–cardiac toxicity is not completely elucidated. The …