TDP1 and TDP2 were discovered and named based on the fact they process 3′-and 5′-
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …

Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a
DNA 3′-end linked to a tyrosyl moiety and has been implicated in the repair of …

Tyrosyl-DNA phosphodiesterase (Tdp1) is a DNA repair enzyme that catalyzes the
hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA 3′-phosphate …

Abstract Tyrosyl–DNA Phosphodiesterases 1 (TDP1) and 2 (TDP2) are eukaryotic enzymes
that clean-up after aberrant topoisomerase activity. While TDP1 hydrolyzes phosphotyrosyl …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a recently discovered enzyme that catalyzes the
hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo following the DNA …

Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond
between a DNA 3′ end and a tyrosyl moiety. In eukaryotic cells, this type of linkage is found …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes
(Top1cc) by hydrolyzing their 3′-phosphotyrosyl DNA bonds and repairs bleomycin …

Tyrosyl DNA phosphodiesterase 1 (TDP1) is a repair enzyme that removes adducts, eg of
topoisomerase I from the 3′-phosphate of DNA breaks. When expressed in human cells as …

Inhibitors of topoisomerase I (Top1) that result in stalled Top1 cleavage complexes (Top1cc)
are commonly employed against cancer. Combination chemotherapy with DNA repair …

DNA is subject to a wide range of insults, resulting from endogenous and exogenous
sources that need to be metabolized/resolved to maintain genome integrity. Tyrosyl-DNA …