Placebos play a vital role in clinical research, but their invasive use in the context of local
anaesthetic blocks is controversial. We assessed whether recently published randomised …

In this issue of Anaesthesia, McGuirk et al. address the ethical legitimacy of utilising
interventional placebo controls in regional anaesthesia [1]. The authors have created a …

Local anaesthetics are widely used throughout medical practice. They are used to induce
anaesthesia and analgesia for surgical procedures and for pain management. Nowadays …

Summary The SHAM (Serious Harm and Morbidity) scale was developed to categorise the
severity of potential complications of placebo control interventions in the context of local …

Although new drugs and techniques may improve outcomes when unintended high blood
levels of local anesthetics occur, the primary focus of daily practice should remain the …

In general, the cardiovascular system is more resistant to the toxic actions of local
anaesthetics than is the central nervous system. However, if sufficient doses and blood …

Résumé Objectif La pratique de l'anesthesie regionale a recemment vecu un second souffle
graˆce ala popularite croissante des techniques echoguidees. Les defenseurs de ces …

In this issue of Regional Anesthesia and Pain Medicine, Rosenberg et al. 1 discuss the
problematic nature of determining maximum recommended doses of local anesthetics to …

There has been a resurgence in the popularity of regional anesthesia in recent years
because of the increasing availability of ultrasound guidance. This journal is receiving …

The current recommendations regarding maximum doses of local anesthetics presented in
textbooks, or by the responsible pharmaceutical companies, are not evidence based (ie …