In tissues, many cells are surrounded by and interact with a three-dimensional soft
extracellular matrix (ECM). Both the physical and biochemical properties of the ECM play a …

The physical and architectural cues of the extracellular matrix (ECM) play a critical role in
regulating important cellular functions such as spreading, migration, proliferation, and …

The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Physical properties of the extracellular matrix (ECM) affect cell behaviors ranging from cell
adhesion and migration to differentiation and gene expression, a process known as …

Materials that can mimic the fibrillar architecture of native extracellular matrix (ECM) while
allowing for independent regulation of viscoelastic properties may serve as ideal, artificial …

The development of hydrogel-based biomaterials represents a promising approach to
generating new strategies for tissue engineering and regenerative medicine. In order to …

Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as
spreading, migration, proliferation and differentiation. However, most studies on cell …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular
matrix. These materials are starting to play important roles in regenerative medicine …