Despite the wide variety of existing therapies, multiple myeloma (MM) remains a disease
with dismal prognosis. Choosing the right treatment for each patient remains one of the …

Multiple myeloma (MM) remains incurable despite the abundance of novel drugs. As it has
been previously shown, preclinical 2D models fail to predict disease progression due to their …

Cancer patients undergo detrimental toxicities and ineffective treatments especially in the
relapsed setting, due to failed treatment attempts. The development of a tool that predicts the …

Purpose Multiple myeloma (MM) is the second most prevalent hematological malignancy
and it remains incurable despite the introduction of several novel drugs. The discrepancy …

Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of
plasma cells in the bone marrow (BM), which remains incurable because most patients …

Specific niches within the tumor bone marrow (BM) microenvironment afford a sanctuary for
multiple myeloma (MM) clones due to stromal cell-tumor cell interactions, which confer …

In vitro culturing of primary multiple myeloma cells (MMC) has been a major challenge as
this plasma cell malignancy depends on the bone marrow environment for its survival. Using …

Abstract 3D-dynamic culture models represent an invaluable tool for a better comprehension
of tumor biology and drug response, as they accurately re-create/preserve the complex …

Multiple myeloma (MM) is a malignancy of terminally-differentiated plasma cells that
develops mainly inside the bone marrow (BM) microenvironment. It is well known that …

Multiple myeloma develops primarily inside the bone marrow microenvironment, that confers
pro-survival signals and drug resistance. 3D cultures that reproduce multiple myeloma-bone …