Recent insights into the biological activities and drug delivery systems of tanshinones

Y Cai, W Zhang, Z Chen, Z Shi, C He… - International Journal of …, 2016 - Taylor & Francis
Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal
herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the …

Enhanced oral bioavailability of Tanshinone IIA using lipid nanocapsules: formulation, in-vitro appraisal and pharmacokinetics

AA Ashour, AA Ramadan, DA Abdelmonsif… - International Journal of …, 2020 - Elsevier
Tanshinone IIA (TSIIA) is a promising phytomedicine that has been extensively studied due
to its numerous biological activities, especially as an anticancer drug. However, it suffers …

Preparation, characterization and cytotoxicity evaluation of tanshinone IIA nanoemulsions

LC Chang, CL Wu, CW Liu, WH Chuo… - Journal of …, 2011 - ingentaconnect.com
Tanshinone IIA (TA) is a major active component of Danshen (Salvia miltiorrhiza bunge), a
wellknown traditional Chinese medicine. In this paper, we describe an optimal method for …

[HTML][HTML] Research and development of natural product tanshinone I: pharmacology, total synthesis, and structure modifications

X Huang, L Jin, H Deng, D Wu, Q Shen… - Frontiers in …, 2022 - frontiersin.org
Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat
cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble …

Pharmacological properties of tanshinones, the natural products from Salvia miltiorrhiza

X Wang, Y Yang, X Liu, X Gao - Advances in pharmacology, 2020 - Elsevier
Abstract Danshen (Cai, et al. 2016) is the dry root and rhizome of the herbaceous plant
Salvia miltiorrhiza Bge. of family labiatae, a perennial plant that is native to China and …

Preparation and enhanced oral bioavailability of cryptotanshinone-loaded solid lipid nanoparticles

LD Hu, Q Xing, J Meng, C Shang - Aaps Pharmscitech, 2010 - Springer
In this study, solid lipid nanoparticles (SLNs) were successfully prepared by an ultrasonic
and high-pressure homogenization method to improve the oral bioavailability of the poorly …

Tanshinone derivatives: a patent review (January 2006–September 2012)

XH Tian, JH Wu - Expert Opinion on Therapeutic Patents, 2013 - Taylor & Francis
Introduction: Tanshinone IIA (TSIIA), cryptotanshinone and tanshinone I are major bioactive
constituents of Danshen, a Chinese herbal medicine. Sodium tanshinone IIA sulfonate (STS) …

Preparation, optimization and cellular uptake study of tanshinone I nanoemulsion modified with lactoferrin for brain drug delivery

Y Wu, B Zhang, D Kebebe, L Guo, H Guo… - Pharmaceutical …, 2019 - Taylor & Francis
Tanshinone I (TSI) is one of the bioactive compound obtained from the root of Salvia
miltiorrhiza which is a well-known traditional Chinese medicine (TCM) used for the treatment …

[HTML][HTML] Sodium tanshinone IIA sulfonate: a review of pharmacological activity and pharmacokinetics

ZY Zhou, WR Zhao, J Zhang, XL Chen… - Biomedicine & …, 2019 - Elsevier
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA)
which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza …

[HTML][HTML] The anticancer properties of tanshinones and the pharmacological effects of their active ingredients

L Fu, B Han, Y Zhou, J Ren, W Cao, G Patel… - Frontiers in …, 2020 - frontiersin.org
Cancer is a common malignant disease worldwide with an increasing mortality in recent
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …