[HTML][HTML] Role of innate immune system in the pathogenesis of ankylosing spondylitis

N Vanaki, S Aslani, A Jamshidi, M Mahmoudi - Biomedicine & …, 2018 - Elsevier
Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a
severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of …

[HTML][HTML] Role of HLA-B27 in the pathogenesis of ankylosing spondylitis

B Chen, J Li, C He, D Li, W Tong… - Molecular medicine …, 2017 - spandidos-publications.com
The study of ankylosing spondylitis (AS) has made significant progress over the last decade.
Genome-wide association studies have identified and further substantiated the role of …

Ankylosing spondylitis: etiology, pathogenesis, and treatments

W Zhu, X He, K Cheng, L Zhang, D Chen, X Wang… - Bone research, 2019 - nature.com
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …

The pathogenesis of ankylosing spondylitis: an update

SJ Pedersen, WP Maksymowych - Current rheumatology reports, 2019 - Springer
Abstract Purpose of Review Ankylosing spondyloarthritis (AS) is a chronic inflammatory
disease that involves the axial joints and entheses. Extra-spinal manifestations such as …

Ankylosing spondylitis: from cells to genes

JF Zambrano-Zaragoza… - International journal …, 2013 - Wiley Online Library
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it
is considered an autoimmune disease. HLA‐B27 is the risk factor most often associated with …

Uncovering the underworld of axial spondyloarthritis

S Del Vescovo, V Venerito, C Iannone… - International journal of …, 2023 - mdpi.com
Axial spondyloarthritis (axial-SpA) is a multifactorial disease characterized by inflammation
in sacroiliac joints and spine, bone reabsorption, and aberrant bone deposition, which may …

Insights into the pathophysiology of ankylosing spondylitis: contributions from animal models

K Braem, RJ Lories - Joint Bone Spine, 2012 - Elsevier
The introduction of anti-tumor necrosis factor strategies has significantly changed the
perspective and outcome of patients with ankylosing spondylitis and related …

Pathogenesis of ankylosing spondylitis: current concepts

JA Smith, E Märker-Hermann, RA Colbert - Best practice & research …, 2006 - Elsevier
More than three decades after the discovery of HLA-B27 as a major genetic clue to the
origins of ankylosing spondylitis, much has been learned about pathogenesis. However, the …

The early phases of ankylosing spondylitis: emerging insights from clinical and basic science

A Watad, C Bridgewood, T Russell… - Frontiers in …, 2018 - frontiersin.org
In our paper, we discuss how the early phases of ankylosing spondylitis (AS) are linked to
peri-firbocartilagenous osteitis in the sacroiliac joint and entheseal bone related anchoring …

Progress in our understanding of the pathogenesis of ankylosing spondylitis

D Simone, MH Al Mossawi, P Bowness - Rheumatology, 2018 - academic.oup.com
AS is a common rheumatic condition characterized by inflammation and new bone
formation. The pathogenesis of AS is likely multifactorial and has not been fully elucidated to …