Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?

Y Huang, MQ Zheng, JM Gerdes - Current topics in medicinal …, 2010 - ingentaconnect.com
The serotonin transporter (SERT) has been implicated in a variety of neuropsychiatric
disorders including depression, schizophrenia, substance abuse, alcoholism, and …

11C and 18F PET radioligands for the serotonin transporter (SERT)

JS Stehouwer, MM Goodman - Journal of Labelled Compounds …, 2013 - Wiley Online Library
The serotonin transporter (SERT) has been implicated in a variety of neuropsychiatric
disorders including depression, anxiety, and suicide, and is the target of the selective …

A New Single-Photon Emission Computed Tomography Imaging Agent for Serotonin Transporters:  [123I]IDAM, 5-Iodo-2-((2-((dimethylamino)methyl)phenyl)thio) …

S Oya, MP Kung, PD Acton, M Mu, C Hou… - Journal of medicinal …, 1999 - ACS Publications
The serotonin reuptake or transporter sites (SERT) are located specifically on the terminals
and cell bodies of the serotonergic neurotransmission system in the brain. They are the …

Synthesis and In Vivo Evaluation of Halogenated N,N-Dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine Derivatives as PET Serotonin Transporter …

N Jarkas, RJ Voll, L Williams, JR Votaw… - Journal of medicinal …, 2008 - ACS Publications
N, N-Dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio) benzylamine (38), substituted on
ring A, was reported to display high binding affinity and selectivity to the human brain …

Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and …

Y Huang, DR Hwang, R Narendran… - Journal of Cerebral …, 2002 - journals.sagepub.com
The recent introduction of a number of new radiotracers suitable for imaging the serotonin
transporters (SERT) has radically changed the field of SERT imaging. Whereas, until …

Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography:  Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of 11C …

AA Wilson, N Ginovart, M Schmidt… - Journal of medicinal …, 2000 - ACS Publications
A series of four 2-(phenylthio) araalkylamines have been radiolabeled with 11C and
evaluated as potential radiotracers for imaging the serotonin transporter (SERT) by positron …

A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C] 2-[2 …

Y Huang, DR Hwang, SA Bae, Y Sudo, N Guo… - Nuclear medicine and …, 2004 - Elsevier
The synthesis, radiolabeling, and in vitro and in vivo evaluation of a new positron emission
tomography (PET) radioligand for the serotonin transporter (SERT),[11C] 2-[2 …

In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2′-((dimethylamino) methyl)-4′-(fluoroalkoxy) phenylthio) benzenamine) for PET imaging of the …

JL Wang, AK Parhi, S Oya, B Lieberman… - Journal of Nuclear …, 2009 - Soc Nuclear Med
PET of the serotonin transporter (SERT) in the brain is a useful tool for examining normal
physiologic functions as well as disease states involving the serotonergic system. The goal …

FlipADAM: a potential new SPECT imaging agent for the serotonin transporter

JL Wang, EC Deutsch, S Oya, HF Kung - Nuclear medicine and biology, 2010 - Elsevier
INTRODUCTION: Single photon emission computed tomography (SPECT) imaging of the
serotonin transporter (SERT) in the brain is a useful tool for examining normal physiological …

Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands

J Vercouillie, S Mavel, L Galineau, T Ragusa… - Bioorganic & medicinal …, 2006 - Elsevier
As the serotonin transporter (SERT) is involved in several neurodegenerative and
psychiatric disorders, radiopharmaceuticals to image the SERT by PET or SPECT would be …