Immune aging is best known for its immune defects that increase susceptibility to infections
and reduce adaptive immune responses to vaccination. In parallel, the aged immune system …

With advancing age, the immune system undergoes changes that predispose to
autoimmune reactivity. Aging reduces the efficiency of physical barriers, decreasing …

Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …

With increasing age, the ability of the adaptive immune system to respond to vaccines and to
protect from infection declines. In parallel, the production of inflammatory mediators …

The relationship between advanced age and immunologic deficits is becoming an area of
rapidly advancing research. Many of the clinical hurdles in the elderly population result from …

Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

At first glance, longevity and immunity appear to be different traits that have not much in
common except the fact that the immune system promotes survival upon pathogenic …

Highlights•There is a general signal transduction alteration in immune cells with human
aging.•The most important changes occur at the proximal signaling of TCR.•Not only the …

Age is an important risk for autoimmunity, and many autoimmune diseases preferentially
occur in the second half of adulthood when immune competence has declined and thymic T …

Immune aging is a complex process rendering the host susceptible to cancer, infection, and
insufficient tissue repair. Many autoimmune diseases preferentially occur during the second …