Extracellular matrix (ECM) deposition during wound healing is a physiological response to
an insult. Wound healing becomes deregulated in the setting of chronic injury or long …

Although the involvement of plasminogen activator inhibitor-1 (PAI-1) in fibrotic diseases is
well documented, its role in cardiac fibrosis remains controversial. The goal of this study was …

Fibrosis is known as a frequent and irreversible pathological condition which is associated
with organ failure. Tissue fibrosis is a central process in a variety of chronic progressive …

Fibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease.
Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive …

Background—Elevated levels of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor
of urokinase plasminogen activator and tissue plasminogen activator, are implicated in the …

Background: Fibrosis is the pathological consequence of stress-induced tissue remodeling
and matrix accumulation. Increased levels of plasminogen activator inhibitor type I (PAI-1) …

Background: The long term survival outcome of patients with IPF is bleak, with a paucity of
effective treatments. Results: The changes in baseline PAI-1 expression regulate fibroblast …

Plasminogen activator inhibitor-1 (PAI-1) plays a critical role in tissue fibrosis by inactivating
matrix metalloproteinases, which might effect on the progression of left ventricular …

Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis. The
progression of renal lesions to fibrosis involves several mechanisms, among which the …

The plasminogen system is a critical proteolytic system responsible for the remodeling of the
extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen …