[HTML][HTML] Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal …

H Chi, G Peng, J Yang, J Zhang, G Song… - Frontiers in …, 2022 - frontiersin.org
Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in
adults and is highly metastatic, resulting in a poor patient prognosis. Sphingolipid …

[HTML][HTML] Single-cell sequencing analysis related to sphingolipid metabolism guides immunotherapy and prognosis of skin cutaneous melanoma

Y Ding, Z Zhao, H Cai, Y Zhou, H Chen, Y Bai… - Frontiers in …, 2023 - frontiersin.org
Background We explore sphingolipid-related genes (SRGs) in skin melanoma (SKCM) to
develop a prognostic indicator for patient outcomes. Dysregulated lipid metabolism is linked …

[HTML][HTML] Integrating single-cell analysis and machine learning to create glycosylation-based gene signature for prognostic prediction of uveal melanoma

J Liu, P Zhang, F Yang, K Jiang, S Sun, Z Xia… - Frontiers in …, 2023 - frontiersin.org
Background Increasing evidence suggests a correlation between glycosylation and the
onset of cancer. However, the clinical relevance of glycosylation-related genes (GRGs) in …

[HTML][HTML] A comprehensive prognostic and immunological analysis of a six-gene signature associated with glycolysis and immune response in uveal melanoma

J Liu, J Lu, W Li - Frontiers in immunology, 2021 - frontiersin.org
Uveal melanoma (UM) is a subtype of melanoma with poor prognosis. This study aimed to
construct a new prognostic gene signature that can be used for survival prediction and risk …

[HTML][HTML] Prognostic signatures of sphingolipids: Understanding the immune landscape and predictive role in immunotherapy response and outcomes of hepatocellular …

X Zhang, J Zhuge, J Liu, Z Xia, H Wang, Q Gao… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a complex disease with a poor outlook for
patients in advanced stages. Immune cells play an important role in the progression of HCC …

[HTML][HTML] Identification of prognostic genes in uveal melanoma microenvironment

H Luo, C Ma - PLoS One, 2020 - journals.plos.org
Background Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults. Many previous studies have demonstrated that the infiltrating of immune and stromal …

[HTML][HTML] Prognostic implications of novel ten-gene signature in uveal melanoma

H Luo, C Ma, J Shao, J Cao - Frontiers in Oncology, 2020 - frontiersin.org
Background: Uveal melanoma (UM) is the most common primary intraocular cancer in
adults. Genomic studies have provided insights into molecular subgroups and oncogenic …

[HTML][HTML] Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma

K Shen, Q Wang, L Wang, Y Yang, M Ren, Y Li… - European Journal of …, 2023 - Springer
Background Melanoma is the deadliest form of skin tumor, and G protein-coupled receptors
(GPCRs) play crucial roles in its carcinogenesis. Furthermore, the tumor microenvironment …

[HTML][HTML] Exploring the role of sphingolipid-related genes in clinical outcomes of breast cancer

S Pei, P Zhang, L Yang, Y Kang, H Chen… - Frontiers in …, 2023 - frontiersin.org
Background Despite tremendous advances in cancer research, breast cancer (BC) remains
a major health concern and is the most common cancer affecting women worldwide. Breast …

Identifying biomarkers associated with immunotherapy response in melanoma by multi-omics analysis

Y He, X Wang - Computers in Biology and Medicine, 2023 - Elsevier
Despite immune checkpoint inhibitors (ICIs) have shown the greatest success in melanoma
treatment, only a subset of melanoma patients responds well to ICIs. Thus, identifying …