Hematopoietic stem cells (HSCs) take on the extraordinary role of sustaining life-long
production of blood cells. Despite their indisputable therapeutic potential, HSC biology is …

Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial
oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed …

The hematopoietic system produces new blood cells throughout life. Mature blood cells all
derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly …

Hematopoiesis is sustained over an entire lifetime through continuous maintenance and self-
renewal of hematopoietic stem cells (HSCs). However, a coherent picture of how these …

Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables
glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic …

Abstract Purpose of Review The well-established crosstalk between hematopoietic stem
cells (HSC) and bone marrow (BM) microenvironment is critical for the homeostasis and …

Hematopoietic stem cells (HSCs) are highly potent cells that can self-renew and differentiate
to replenish all blood cells throughout life. Quiescence is a fundamental property of HSCs …

Quiescent and self‐renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than
on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance …

Lifelong production of blood by hematopoietic stem and progenitor cells is regulated by a
balance of self-renewal of stem cells, maintaining their limited supply throughout life; and …

Hematopoietic stem cells (HSCs) are stem cells from mesodermal derivation that reside in
bone marrow and provide blood cells for the whole life of an adult individual, through a …