[HTML][HTML] Development and validation of a scoring system to predict outcomes of vedolizumab treatment in patients with Crohn's disease

PS Dulai, BS Boland, S Singh, K Chaudrey… - Gastroenterology, 2018 - Elsevier
Background & Aims As more treatment options for inflammatory bowel diseases become
available, it is important to identify patients most likely to respond to different therapies. We …

Predicting corticosteroid-free biologic remission with vedolizumab in Crohn's disease

AK Waljee, B Liu, K Sauder, J Zhu… - Inflammatory Bowel …, 2018 - academic.oup.com
Abstract Background and Aims Vedolizumab (VDZ) is effective for Crohn's disease (CD) but
costly and is slow to produce remission. Early knowledge of whether vedolizumab is likely to …

Vedolizumab as induction and maintenance therapy for Crohn's disease

WJ Sandborn, BG Feagan, P Rutgeerts… - … England Journal of …, 2013 - Mass Medical Soc
Background The efficacy of vedolizumab, an α4β7 integrin antibody, in Crohn's disease is
unknown. Methods In an integrated study with separate induction and maintenance trials …

Three‐year effectiveness and safety of vedolizumab therapy for inflammatory bowel disease: a prospective multi‐centre cohort study

A Amiot, M Serrero, L Peyrin‐Biroulet… - Alimentary …, 2019 - Wiley Online Library
Background Cohort studies have described the short‐term effectiveness and safety of
vedolizumab in treating patients with Crohn's disease (CD) and ulcerative colitis (UC), but …

Comparative safety and effectiveness of vedolizumab to tumour necrosis factor antagonist therapy for Crohn's disease

M Bohm, R Xu, Y Zhang, S Varma… - Alimentary …, 2020 - Wiley Online Library
Background Direct comparisons are lacking between vedolizumab and tumour necrosis
factor (TNF)‐antagonist therapy in Crohn's disease (CD). Aim To compare safety and …

Vedolizumab as induction and maintenance therapy for Crohn's disease in patients naïve to or who have failed tumor necrosis factor antagonist therapy

BE Sands, WJ Sandborn, G Van Assche… - Inflammatory bowel …, 2017 - academic.oup.com
Background Vedolizumab is a gut-selective α4β7 integrin antagonist for the treatment of
moderately to severely active Crohn's disease (CD). Aims of this study were to characterize …

Vedolizumab induces endoscopic and histologic remission in patients with Crohn's disease

M Löwenberg, S Vermeire, N Mostafavi, F Hoentjen… - Gastroenterology, 2019 - Elsevier
Background & Aims We evaluated the ability of vedolizumab to induce endoscopic and
histologic remission in patients with Crohn's disease (CD). Methods We performed a …

[HTML][HTML] Endoscopic, radiologic, and histologic healing with vedolizumab in patients with active Crohn's disease

S Danese, WJ Sandborn, JF Colombel, S Vermeire… - Gastroenterology, 2019 - Elsevier
Background & Aims Vedolizumab is a gut-selective monoclonal antibody for the treatment of
moderately to severely active Crohn's disease (CD). We performed a prospective study of …

A clinical decision support tool may help to optimise vedolizumab therapy in Crohn's disease

PS Dulai, A Amiot, L Peyrin‐Biroulet… - Alimentary …, 2020 - Wiley Online Library
Background A clinical decision support tool (CDST) has been validated for predicting
treatment effectiveness of vedolizumab (VDZ) in Crohn's disease. Aim To assess the utility of …

Loss of response to vedolizumab and ability of dose intensification to restore response in patients with Crohn's disease or ulcerative colitis: a systematic review and …

L Peyrin-Biroulet, S Danese, M Argollo… - Clinical …, 2019 - Elsevier
Background & Aims Vedolizumab is effective and safe for the treatment of Crohn's disease
(CD) and ulcerative colitis (UC). Little is known about the incidence rate of loss of response …