Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust
replication in large-scale genome-wide association studies. To understand the role of DNA …

Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …

Background We investigated a cross-sectional epigenome-wide association study of
patients with early and late diabetes-associated chronic kidney disease (CKD) to identify …

A subset of individuals with type 1 diabetes will develop diabetic kidney disease (DKD).
DKD is heritable and large-scale genome-wide association studies have begun to identify …

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …

Context There is a growing body of evidence that epigenetic changes including DNA
methylation influence the risk of type 2 diabetes (T2D) and its microvascular complications …

Background The aim of this study was to evaluate whether global levels of DNA methylation
status were associated with albuminuria and progression of diabetic nephropathy in a case …

Variation in DNA methylation (DNAmet) in white blood cells and other cells/tissues has been
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …

Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …

Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …