Immunostimulatory oligodeoxynucleotides (ODN) containing cytosine-guanine (CpG) motifs
are powerful stimulators of innate as well as adaptive immune responses, exerting their …

We have previously demonstrated that the immune response to an unmethylated cytidine–
guanosine (CpG)-containing oligonucleotide (ODN) is greatly enhanced when encapsulated …

Unmethylated cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG-ODNs)
exhibit potent immunostimulating activity by binding with Toll-like receptor 9 (TLR9) …

Although it is well documented that the immunological activity of cytosine–guanine (CpG)
motifs is abrogated by 5′ methylation of the cytosine residue, encapsulation within …

Viral nucleic acids are recognized by specific pattern-recognition receptors of the Toll-like
and RIG-I-like receptor families. Synthetic DNA and RNA oligonucleotides can activate the …

Immunostimulatory CpG oligodeoxynucleotides (ODN) have been tested as
immunoadjuvants for various vaccines including T-cell independent (TI) antigens. Findings …

The main objective of these studies was to investigate whether the nanoparticle delivery has
any immunopotentiation effect at modest doses of a few micro-or nanograms of CpG …

Unmethylated cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) are
recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and …

The therapeutic benefit from phosphorothioate oligodeoxynucleotides (PS ODN) containing
immune stimulatory sequences (ISS) has been demonstrated in animal models of cancer …

Immunostimulatory CpG oligonucleotides (ODN) show promise as immune adjuvants, anti-
allergens, and immunoprotective agents. Increasing the bioavailability and duration of action …