Recent research has uncovered extensive variability in the boundaries of transcript isoforms,
yet the functional consequences of this variation remain largely unexplored. Here, we …

Active human promoters produce promoter-upstream transcripts (PROMPTs). Why these
RNAs are coupled to decay, whereas their neighboring promoter-downstream mRNAs are …

Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites,
express mRNA isoforms with variable 3′ untranslated regions (UTRs). By systematic …

Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing
that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for …

We show here that expression of genes from convergent transcription units can be regulated
by the formation of double-stranded RNA (dsRNA) in the region of overlapping …

Alternative polyadenylation generates numerous 3′ mRNA isoforms that can differ in their
stability, structure, and function. These isoforms can be used to map mRNA stabilizing and …

Background The 3′ untranslated region (UTR) plays critical roles in determining the level of
gene expression through effects on activities such as mRNA stability and translation …

Polyadenylation is a 3′ mRNA processing event that contributes to gene expression by
affecting stability, export and translation of mRNA. Human polyadenylation signals (PAS) …

Poly (A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called
cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has …

Polyadenylation is thought to be involved in the degradation and quality control of bacterial
RNAs but relatively few examples have been investigated. We used a combination of 5΄ …