Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular
correlate of the hyperpolarization-activated current (If/Ih), are membrane proteins which play …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Background—Inhibition of cardiac sympathetic tone represents an important strategy for
treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Hyperpolarization and Cyclic Nucleotide (HCN)-gated channels represent the molecular
correlates of the “funny” pacemaker current (If), a current activated by hyperpolarization and …

Hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels were first reported
in heart cells and are recently known to be involved in a variety of neural functions in healthy …

ZD7288 has been widely used as a tool in the study of hyperpolarization-activated cyclic
nucleotide-gated channels (HCN channels), and to test the relationships between HCN …

Higher heart rate (HR) is independently related to worse outcomes in various cardiac
diseases, including hypertension, coronary artery disease, and heart failure (HF). HR is …

Hyperpolarization-activated cation channels of the HCN gene family are crucial for the
regulation of cell excitability. Importantly, these channels play a pivotal role in the control of …