Proteins are effector molecules that mediate the functions of genes, and modulate
comorbidities,,,,,,–, behaviors and drug treatments. They represent an enormous potential …

Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …

High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …

Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

Cardiometabolic diseases are frequently polygenic in architecture, comprising a large
number of risk alleles with small effects spread across the genome,–. Polygenic scores …

Blood circulating proteins are confounded readouts of the biological processes that occur in
different tissues and organs. Many proteins have been linked to complex disorders and are …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

Proteins in the circulatory system mirror an individual's physiology. In daily clinical practice,
protein levels are generally determined using single-protein immunoassays. High …

The increasing prevalence of type 2 diabetes poses a major challenge to societies
worldwide. Blood-based factors like serum proteins are in contact with every organ in the …

Studying the plasma proteome as the intermediate layer between the genome and the
phenome has the potential to identify new disease processes. Here, we conducted a cis …