Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among
prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain …

A number of bacterial species, mostly proteobacteria, possess monothiol glutaredoxins
homologous to the Saccharomyces cerevisiae mitochondrial protein Grx5, which is involved …

Monothiol glutaredoxins (Grxs) with a noncanonical CGFS active site are found in all
kingdoms of life. They include members with a single domain and thioredoxin-Grx fusion …

Grx5 defines a family of yeast monothiol glutaredoxins that also includes Grx3 and Grx4. All
three proteins display significant sequence homology with proteins found from bacteria to …

Glutaredoxins are thiol oxidoreductases that regulate protein redox state. In Saccharomyces
cerevisiae, Grx1 and Grx2 are cytosolic dithiol glutaredoxins, whereas Grx3, Grx4, and Grx5 …

Mammalian glutaredoxin 3 (Grx3/PICOT) is an essential protein involved in the regulation of
signal transduction, for instance during immune cell activation and development of cardiac …

The Saccharomyces cerevisiae monothiol glutaredoxin Grx5 participates in the
mitochondrial biogenesis of iron–sulfur clusters. Grx5 homologues exist in organisms from …

Abstract Significance: Glutaredoxins (Grxs) are small oxidoreductases of the thioredoxin
family of proteins regulating the thiol redox state of several proteins. Thereby, Grxs are key …

Glutaredoxins (Grxs) are glutathione‐dependent oxidoreductases that belong to the
thioredoxin superfamily catalyzing thiol‐disulfide exchange reactions via active site cysteine …

Most cells contain high levels of glutathione and multiple glutaredoxins, which utilize the
reducing power of glutathione to catalyze disulfide reductions in the presence of NADPH …