Background: The immune response to acute cerebral ischemia is a major factor in stroke
pathobiology. Circadian biology modulates some aspects of immune response. The goal of …

Ischemic stroke is caused by obstructed cerebral blood flow, which results in neurological
injury and poor outcomes. Pro-inflammatory signaling from both residential and infiltrating …

Stroke is a leading cause of disability and death worldwide. There is evidence that there is a
circadian rhythm in stroke with peak occurrence in the morning (6 to 10 am). However, it is …

Circadian rhythms are endogenous biological cycles that regulate physiology and behavior
and are set to precisely 24-h by light exposure. Light at night (LAN) dysregulates physiology …

Occurrence of stroke cases displays a time-of-day variation in human. However, the
mechanism linking circadian rhythm to the internal response mechanisms against …

Accumulating evidence suggests that astrocytes, the abundant cell type in the central
nervous system (CNS), play a critical role in maintaining the immune response after cerebral …

Background and Purpose—Ischemic stroke leads to significant morbidity and mortality in the
Western world. Early reperfusion strategies remain the treatment of choice but can initiate …

Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in
the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in …

The occurrence of stroke in humans peaks in the morning. A recent study revealed that time
of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might …

Rhythmicity of the circadian system is a 24-hour period, driven by transcription-translation
feedback loops of circadian clock genes. The central circadian pacemaker in mammals is …