Increasing evidence from animal and human studies suggests that inflammation may be
involved in mood disorders. Sickness behavior and emotional changes induced by …

Background Aggression, hyperactivity, impulsivity, helplessness and anhedonia are all
signs of depressive-like disorders in humans and are often reported to be present in animal …

Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral
changes indicative of depression. The present study sought to explore whether LPS is able …

Substantial evidence indicates an association between clinical depression and altered
immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly …

Chronic activation of immune-inflammatory and oxidative and nitrosative stress (O&NS)
pathways plays an important role in the pathophysiology of clinical depression. Increased …

The fact that there is a complex and bidirectional communication between the immune and
nervous systems has been well demonstrated. Lipopolysaccharide (LPS), a component of …

Systemic inflammation leads to a variety of physiological (eg fever) and behavioral (eg
anorexia, immobility, social withdrawal, depressed mood, disturbed sleep) responses that …

Systemic administration of lipopolysaccharide (LPS) induces sickness behaviors, as well as
alterations of hypothalamic–pituitary–adrenal functioning commonly associated with …

What do we know about sickness behavior? In this article, I guide you through some of the
complexity of sickness behavior occurring after an immune challenge. I highlight the many …

Infection commonly triggers nonspecific psychological and behavioral changes including
fatigue and malaise, anhedonia, inability to concentrate, and disturbed sleep that collectively …