There is now increasing evidence that a constitutive expression of cyclooxygenase 2 (COX-
2) plays a role in the development and progression of malignant ectodermal tumours. In this …

Abstract Cyclooxygenase (COX)-2 is an inducible enzyme involved in production of
prostaglandins in inflammatory processes. There is now increasing evidence that a …

Cyclooxygenase 2 (COX-2) is an inducible enzyme involved in the production of
prostaglandins and thromboxanes during inflammation. There are now several lines of …

Earlier observations on cyclo-oxygenase inhibitors (NSAIDs) restricting tumor growth were
re-evaluated by comparing the effects of non-selective, preferential selective and selective …

Abstract Cyclooxygenase-2 (COX-2) is an enzyme that plays an important role in the
production of prostaglandins. Numerous studies have demonstrated increased levels of …

The expression of cyclooxygenase-2 (COX-2) has been reported as an indicator of poor
prognosis in a wide variety of human tumors, including colon, breast and uveal melanoma …

Both nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX) 2-selective
inhibitors such as celecoxib are being reported as having potent anticancer activity in …

Abstract Cyclooxygenase-2 (COX-2) is known to be involved in tumour progression and has
been suggested as a therapeutic target in many human and animal malignancies. A number …

The biological significance of the almost constant presence of macrophages in the tumoral
microenvironment is an issue debated by several authors. The major difficulty in …

The potential interaction between cyclooxygenase (Cox) and NO metabolic pathways in the
control of local tumor growth was evaluated. Mice bearing either a sarcoma-derived tumor …